Here's a small sampling of the research projects we are working on:
Microsecond Dynamics of Zinc Fingers
How does zinc affect the stability and conformational flexibility of zinc fingers? How do disease-associated mutants affect protein dynamics? How can we use this information to design better theraputics?
Dynamics of therapuetic nucleic acids polymers
What are the conformations adopted by these polymers? How do they interact with different ions? How can we improve them as therapeutics?
Protein-aptamer dynamics and energy landscapes
What are the dynamics of aptamers? How does protein binding change them, and how do they change protein dynamics? How can we improve their design?
We have other research projects focusing on explicit drug design and development and/or on microsecond-scale simulations of other proteins, nucleic acids, and complexes.