Course info: SCB 710
Time and Place Foothills, 4th Monday (most months) 3:30 -5:00. Talk starts at 4pm.
Course Instructor Professor Salsbury
Contact Info firstname.lastname@example.org, Olin 301A
This course is a discussion group in which faculty, postdocs and graduate students in the SCB program present, listen to and discuss current research at Wake Forest in structural & computational biophysics and biology.
September 24 2018 Wayne Hemphill (Biochemistry) “TREX1 Inhibition as a Novel Cancer Immunotherapy “
October 22 2018 Ferdiemar Guinto (SCB T32 recipient, Chemistry) “TBA”
September 25 2017 Ryan Melvin (SCB T32 recipient, Physics, and Mathematics & Statistics) "Community-relative distance with applications to biophysics"
October 23 2017 Stephen Rego (Biochemistry) "TREX1 in autophagy-dependent degradation of intrinsic cytosolic DNA"
Jan 29 2018 David Ornelles (Microbiology and Immunology) "A quantitative view of translation"
March 26 2018 Jiajie Xaio (Physics and Computer Science) "Kmer-based sequence classification and de novo discriminating motif discovery"
June 5 2018 George Holzwarth (Physics) "Bayesian analysis of single-particle tracks to study motion in live cells." co-sponsored by the Department of Physics and the SCB Training Grant.
September 26 2016 Leslie Poole (Biochemistry) "Catalysis by peroxiredoxins at high temporal and structural resolution"
October 31 2016 Emil Nilsson (SCB T32 recipient, Chemistry, SCB Certificate Student) "Translational fidelity and increased bacterial fitness"
Feb 27 2017 Martin Guthold (Physics) "High-throughput binding kinetics & drug discovery on a next-generation sequencing chip" and Roy Hantgan (Biochemistry) "Biophysics Benchmarks Binding!"
March 27 2017 Ryan Davis (SCB T32 recipient, Biochemistry) "TBA"
September 28 2015 Sam Cho (Physics and CS) and Uli Bierbach (Chemistry) "Computational and Experimental Characterization of rDNA and rRNA G-Quadruplexes and Their Interactions with Small Molecules."
October 26 2015 Adam Hall (Biomedical Engineering) "DNA Base Modification Detection and Sequence Selection Using Solid-State Nanopores"
Feb 22 2016 Marin Guthold (Physics) "Fascinating Fibrin Fibers"
March 28 2016 Ryan Godwin (SCB T32 recipient, Physics, SCB Certificate Student) "Finding NEMO: Molecular Dynamics Simulations of Zinc Fingers"
April 25 2016 Chris Mauney (SCB T32 recipient, Biochemistry, SCB Certificate Student) "The dNTP triphosphohydrolase SAMHD1 is a redox-regulated enzyme"
June 13 2016 Jeremiah Keyes (Biochemistry) "Regulation of Erk signal transduction by signal-induced cysteine oxidation"
Doug Lyles (Biochemistry) "Migration of Cytoplasmic Particle and Organelles in Virus-Infected Cells"
Jade Mims (SCB T32 recipient, Molecular Medicine) "Integrated “omics” approach to discover therapies for radiation resistant head and neck cancer"
Mark Lively (Biochemistry) "Science Funding and Shaping Science Policy"
Rebecca Alexander (Chemistry) "Structural Integrity and conformational flexibility of transfer RNA"
Adam Hall (BME) "Detecting and Quantifying DNA Structural and Chemical Modifications at the Single Molecule Level"
William Turkett (CS) "Algorithms to Detect sequence motifs and to predict post-translational modification sites"
Jason Fye (Biochemistry, SCB Certificate graduate) "Aberrant dsDNA metabolism in TREX1-associated immune dysfunction"
Kim Nelson (Biochemistry) "Identifying structural features influencing the sensitivity of Peroxiredoxins to inactivation using active site profiling and clustering analysis"
Janelle Leuthauser (SCB T32 recipient, Molecular Genetics) "Protein similarity networks based on sequence, structure, and active site environment"
Jacque Fetrow (Physics & CS) "What do all those proteins do? An approach to functionally relevant clustering of the protein universe"
Thomas Poole (SCB T32 recipient, Chemistry) "Synthesis and use of more reactive sulfenic acid probes"
Amanda Smelser (SCB T32 recipient, Biochemistry, SCB Certificate Student) "Viscoelastic properties of normal, tumorigenic and metastatic breast cells"
Tom Hollis (Biochemistry) "DNA Recognition and Transcriptional Regulation of Bacterial Virulence Genes" "
Andrea Belanger (SCB T32 recipient, Physics) "Osmotic Deformability of Red Blood Cells during Storage and Transfusion"
Cristina Furdui (Molecular Medicine) "Redox Regulation of Akt2 by ROS-inducing Signaling Cues"
Uli Bierbach (Chemistry) "Biochemical and Biophysical Studies of DNA-Targeted Platinum-Intercalator Agents"
Jim Norris (Math) and David John (CS) "Hierarchical Bayesian system network modeling of multiple related replicates"
Jed Macosko (Physics) "The Biobook Project: how to reinvent e-textbooks before it's too late"
Todd Lowther (Biochemistry) "Targeting Hydroxyproline Metabolism for Primary Hyperoxaluria and Kidney Stone Formation"
Laura Dillon (SCB T32 recipient, Biochemistry) "DNA Secondary Structures Invovled in Fragile Site Breakage from the Study of Human Chromosome 10"
Edward Allen (Math) "Fuzzy logic modeling of time series data"
Sam Cho (Physics & CS) "RNA folding and Ribosome assembly"
Leslie Poole (Biochemistry) "Where do the cysteine-dependent peroxidases fit into the world of redox signaling? "
Paul Pauca (CS) "Integrated and Computational Imaging"
Lindsay Comstock (Chemistry) "Probing Biological Modifications Through Cofactor Mimicry "
Larry Daniel (Biochemistry) "Redox Control of Cell Growth and Death"
Rebecca Alexander (Chemistry) "Biochemical and computational analysis of protein dynamics"
Yuh-hwa Wang (Biochemistry) "Human chromosomal fragile sites and cancer"
Keith Bonin (Physics) "Optogenetics"
John Wilkinson (Biochemistry) "The multiple personalities of apoptosis inducing factor: from cell killer to cancer promoter"
Timo Thonhauser (Physics) "A DFT approach for Modeling DNA Intercalation"
Patricia Dos Santos (Chemistry) "Identifying bacterial pathways for Fe-S cluster assembly"
Jim Norris (Math) "Probability-based continuous network modeling of short time course data"
Tom Hollis & Fred Perrino (Biochemistry) "Structure and function of the mammalian RNase H2 complex"
Peter Antinozzi (Biochemistry) ""Functional mapping of disease-susceptibility loci: RNAi screens and high-content imaging"
Martin Guthold (Physics) & Roy Hantgan (Biochemistry) "Measuring the dynamic strength of integrin:fibrin adhesive forces"
Jim Curran (Biology) "Ribosomal Proctology: Probing the Exit Site"
Roy Hantgan (Biochemistry) "Macromolecular Interactions Core Laboratory's Tricks of the Trade"
Cristina Furdui (Molecular Medicine) "A Kinetics Approach to Oncoproteomics: the Missing Link to Personalized Medicine"
Freddie Salsbury (Physics) "Protein Electrostatics, Dynamics, Structure and Function (or Stuff Fred Likes)"
William Turkett (CS) "Probabilistic Approaches to Clustering and Motif Analysis (PACMAN)"
Dany Kim-Shaprio (Physics) "Nitric Oxide Scavenging in Health, Disease and Therapeutic"
David John (CS) "Modeling signaling pathways in chondrocytes"
Doug Lyles (Biochemistry) "Structure of viral nucleoprotein-matrix complexes"
Martin Guthold (Physics) "The extreme viscoelastic properties of fibrin fibers"
Jacque Fetrow (Physics & Computer Science) "Structure and dynamics of peroxiredoxin functional sites"
Linda McPhail (Biochemistry) "NADPH Oxidase: redox and regulation"
2005-06 (This is the year we moved to Foothills; were we have been ever since.)
Jason Grayson (Microbiology & Immunology) "T Cell Death During Viral Infection"
William Turkett (CS) "Reconstructing Biological Networks through Bayesian Network Learning"
Gloria Muday (Biology) "Understanding hormone response using genome-wide transcription analysis in Arabidopsis thaliana"
Jed Macosko (Physics) "Want to Look Inside an Axon? Call MEDIC! Motion Enhanced Differential Interference Constrast Microscopy"
Larry Daniel (Biochemistry)
2004-05 (We were at Lucky 32.)
Leslie Poole (Biochemistry) "Profiling of redox-sensitive signaling proteins via cysteine sulfenic acid detection: combing computational and chemical analysis tools for biological discovery"
Ed Allen (Math) & David John (CS) "Dependency modeling of biological signaling networks using computational algebraic algorithms, Monte Carlo methods and game theoretic techniques"
Rebecca Alexander (Chemistry) "Dissecting inter-domain communication in methionyl-tRNA synthetase"
Roy Hantgan (Biochemistry) "Perils of Prediction"
David Horita (Biochemistry) "TBA"
Freddie Salsbury (Physics) "Computational Studies of Mismatch Repair Proteins"
2003-04 ( The first two were at Ryan's in the Fall. We then moved to Lucky 32 in the Spring.)
Fred Perrino (Biochemistry) 'The metazoan 3'->5' deoxyribonucleases encoded by the TREX genes"
Paul Hemler (CS) "Enhancement of Blood Vessels in Computed Tomography Images of the Liver"
Daniel Kim-Shapiro (Physics) "What's right about nitrite"
Mary Sorci-Thomas (Pathology) "ApoA-I Structure and Function: Studies of a Lipid Binding Protein and Co-Activator for Cholesterol Esterification"
Todd Lowther (Biochemistry)"Molecular Basis for repair of oxidized methionine: A fountain of youth?"
Bernie Brown (Chemistry) "Archael Box C/D sRNP complexes: Recent structural and