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Course info: SCB 710

Time and Place Foothills, 4th Monday (most months) 3:30 -5:00. Talk starts at 4pm.
Course Instructor Professor Salsbury  
Contact Info salsbufr@wfu.edu, Olin 301A

Course Overview 

This course is a discussion group in which faculty, postdocs and graduate students in the SCB program present, listen to and discuss current research at Wake Forest in structural & computational biophysics and biology.

Schedule

  • September 24 2018 Wayne Hemphill (Biochemistry) “TREX1 Inhibition as a Novel Cancer Immunotherapy “

  • October 22 2018 Ferdiemar Guinto (SCB T32 recipient, Chemistry) “TBA”

Previous Years

2017-2018

  • September 25 2017 Ryan Melvin (SCB T32 recipient, Physics, and Mathematics & Statistics) "Community-relative distance with applications to biophysics"

  • October 23 2017 Stephen Rego (Biochemistry) "TREX1 in autophagy-dependent degradation of intrinsic cytosolic DNA"

  • Jan 29 2018 David Ornelles (Microbiology and Immunology) "A quantitative view of translation"

  • March 26 2018 Jiajie Xaio (Physics and Computer Science) "Kmer-based sequence classification and de novo discriminating motif discovery"

  • June 5 2018 George Holzwarth (Physics) "Bayesian analysis of single-particle tracks to study motion in live cells." co-sponsored by the Department of Physics and the SCB Training Grant.

2016-17

  • September 26 2016 Leslie Poole (Biochemistry) "Catalysis by peroxiredoxins at high temporal and structural resolution"

  • October 31 2016 Emil Nilsson (SCB T32 recipient, Chemistry, SCB Certificate Student) "Translational fidelity and increased bacterial fitness"

  • Feb 27 2017 Martin Guthold (Physics) "High-throughput binding kinetics & drug discovery on a next-generation sequencing chip" and Roy Hantgan (Biochemistry) "Biophysics Benchmarks Binding!"

  • March 27 2017 Ryan Davis (SCB T32 recipient, Biochemistry) "TBA"

2015-16

  • September 28 2015 Sam Cho (Physics and CS) and Uli Bierbach (Chemistry) "Computational and Experimental Characterization of rDNA and rRNA G-Quadruplexes and Their Interactions with Small Molecules."

  • October 26 2015 Adam Hall (Biomedical Engineering) "DNA Base Modification Detection and Sequence Selection Using Solid-State Nanopores"

  • Feb 22 2016 Marin Guthold (Physics) "Fascinating Fibrin Fibers"

  • March 28 2016 Ryan Godwin (SCB T32 recipient, Physics, SCB Certificate Student) "Finding NEMO: Molecular Dynamics Simulations of Zinc Fingers"

  • April 25 2016 Chris Mauney (SCB T32 recipient, Biochemistry, SCB Certificate Student) "The dNTP triphosphohydrolase SAMHD1 is a redox-regulated enzyme"

  • June 13 2016 Jeremiah Keyes (Biochemistry) "Regulation of Erk signal transduction by signal-induced cysteine oxidation"

2014-15

  • Doug Lyles (Biochemistry) "Migration of Cytoplasmic Particle and Organelles in Virus-Infected Cells"

  • Jade Mims (SCB T32 recipient, Molecular Medicine) "Integrated “omics” approach to discover therapies for radiation resistant head and neck cancer"

  • Mark Lively (Biochemistry) "Science Funding and Shaping Science Policy"

  • Rebecca Alexander (Chemistry) "Structural Integrity and conformational flexibility of transfer RNA"

  • Adam Hall (BME) "Detecting and Quantifying DNA Structural and Chemical Modifications at the Single Molecule Level"

  • William Turkett (CS) "Algorithms to Detect sequence motifs and to predict post-translational modification sites"

2013-14

  • Jason Fye (Biochemistry, SCB Certificate graduate) "Aberrant dsDNA metabolism in TREX1-associated immune dysfunction"

  • Kim Nelson (Biochemistry) "Identifying structural features influencing the sensitivity of Peroxiredoxins to inactivation using active site profiling and clustering analysis"

  • Janelle Leuthauser (SCB T32 recipient, Molecular Genetics) "Protein similarity networks based on sequence, structure, and active site environment"

  • Jacque Fetrow (Physics & CS) "What do all those proteins do? An approach to functionally relevant clustering of the protein universe"

  • Thomas Poole (SCB T32 recipient, Chemistry) "Synthesis and use of more reactive sulfenic acid probes"

  • Amanda Smelser (SCB T32 recipient, Biochemistry, SCB Certificate Student) "Viscoelastic properties of normal, tumorigenic and metastatic breast cells"

2012-13

  • Tom Hollis (Biochemistry) "DNA Recognition and Transcriptional Regulation of Bacterial Virulence Genes" "

  • Andrea Belanger (SCB T32 recipient, Physics) "Osmotic Deformability of Red Blood Cells during Storage and Transfusion"

  • Cristina Furdui (Molecular Medicine) "Redox Regulation of Akt2 by ROS-inducing Signaling Cues"

  • Uli Bierbach (Chemistry) "Biochemical and Biophysical Studies of DNA-Targeted Platinum-Intercalator Agents"

  • Jim Norris (Math) and David John (CS) "Hierarchical Bayesian system network modeling of multiple related replicates"

2011-12

  • Jed Macosko (Physics) "The Biobook Project: how to reinvent e-textbooks before it's too late"

  • Todd Lowther (Biochemistry) "Targeting Hydroxyproline Metabolism for Primary Hyperoxaluria and Kidney Stone Formation"

  • Laura Dillon (SCB T32 recipient, Biochemistry) "DNA Secondary Structures Invovled in Fragile Site Breakage from the Study of Human Chromosome 10"

  • Edward Allen (Math) "Fuzzy logic modeling of time series data"

2010-11

  • Sam Cho (Physics & CS) "RNA folding and Ribosome assembly"

  • Leslie Poole (Biochemistry) "Where do the cysteine-dependent peroxidases fit into the world of redox signaling? "

  • Paul Pauca (CS) "Integrated and Computational Imaging"

  • Lindsay Comstock (Chemistry) "Probing Biological Modifications Through Cofactor Mimicry "

  • Larry Daniel (Biochemistry) "Redox Control of Cell Growth and Death"

2009-10

  • Rebecca Alexander (Chemistry) "Biochemical and computational analysis of protein dynamics"

  • Yuh-hwa Wang (Biochemistry) "Human chromosomal fragile sites and cancer"

  • Keith Bonin (Physics) "Optogenetics"

  • John Wilkinson (Biochemistry) "The multiple personalities of apoptosis inducing factor: from cell killer to cancer promoter"

  • Timo Thonhauser (Physics) "A DFT approach for Modeling DNA Intercalation"

2008-09

  • Patricia Dos Santos (Chemistry) "Identifying bacterial pathways for Fe-S cluster assembly"

  • Jim Norris (Math) "Probability-based continuous network modeling of short time course data"

  • Tom Hollis & Fred Perrino (Biochemistry) "Structure and function of the mammalian RNase H2 complex"

  • Peter Antinozzi (Biochemistry) ""Functional mapping of disease-susceptibility loci: RNAi screens and high-content imaging"

  • Martin Guthold (Physics) & Roy Hantgan (Biochemistry) "Measuring the dynamic strength of integrin:fibrin adhesive forces"

2007-08

  • Jim Curran (Biology) "Ribosomal Proctology: Probing the Exit Site"

  • Roy Hantgan (Biochemistry) "Macromolecular Interactions Core Laboratory's Tricks of the Trade"

  • Cristina Furdui (Molecular Medicine) "A Kinetics Approach to Oncoproteomics: the Missing Link to Personalized Medicine"

  • Freddie Salsbury (Physics) "Protein Electrostatics, Dynamics, Structure and Function (or Stuff Fred Likes)"

  • William Turkett (CS) "Probabilistic Approaches to Clustering and Motif Analysis (PACMAN)"

2006-07

  • Dany Kim-Shaprio (Physics) "Nitric Oxide Scavenging in Health, Disease and Therapeutic"

  • David John (CS) "Modeling signaling pathways in chondrocytes"

  • Doug Lyles (Biochemistry) "Structure of viral nucleoprotein-matrix complexes"

  • Martin Guthold (Physics) "The extreme viscoelastic properties of fibrin fibers"

  • Jacque Fetrow (Physics & Computer Science) "Structure and dynamics of peroxiredoxin functional sites"

  • Linda McPhail (Biochemistry) "NADPH Oxidase: redox and regulation"

2005-06 (This is the year we moved to Foothills; were we have been ever since.)

  • Jason Grayson (Microbiology & Immunology) "T Cell Death During Viral Infection"

  • William Turkett (CS) "Reconstructing Biological Networks through Bayesian Network Learning"

  • Gloria Muday (Biology) "Understanding hormone response using genome-wide transcription analysis in Arabidopsis thaliana"

  • Jed Macosko (Physics) "Want to Look Inside an Axon? Call MEDIC! Motion Enhanced Differential Interference Constrast Microscopy"

  • Larry Daniel (Biochemistry)

2004-05 (We were at Lucky 32.)

  • Leslie Poole (Biochemistry) "Profiling of redox-sensitive signaling proteins via cysteine sulfenic acid detection: combing computational and chemical analysis tools for biological discovery"

  • Ed Allen (Math) & David John (CS) "Dependency modeling of biological signaling networks using computational algebraic algorithms, Monte Carlo methods and game theoretic techniques"

  • Rebecca Alexander (Chemistry) "Dissecting inter-domain communication in methionyl-tRNA synthetase"

  • Roy Hantgan (Biochemistry) "Perils of Prediction"

  • David Horita (Biochemistry) "TBA"

  • Freddie Salsbury (Physics) "Computational Studies of Mismatch Repair Proteins"

2003-04 ( The first two were at Ryan's in the Fall. We then moved to Lucky 32 in the Spring.)

  • Fred Perrino (Biochemistry) 'The metazoan 3'->5' deoxyribonucleases encoded by the TREX genes"

  • Paul Hemler (CS) "Enhancement of Blood Vessels in Computed Tomography Images of the Liver"

  • Daniel Kim-Shapiro (Physics) "What's right about nitrite"

  • Mary Sorci-Thomas (Pathology) "ApoA-I Structure and Function: Studies of a Lipid Binding Protein and Co-Activator for Cholesterol Esterification"

  • Todd Lowther (Biochemistry)"Molecular Basis for repair of oxidized methionine: A fountain of youth?"

  • Bernie Brown (Chemistry) "Archael Box C/D sRNP complexes: Recent structural and